Medicinal Chemistry - Pharmacy Department
Chapter 0: Introduction to Medicinal Chemistry
1. Introduction to Medicinal Chemistry
2. Processes of Drug Discovery - Medicinal Chemistry
3. Drug Discovery and Design a Historical Outline - Medicinal Chemistry
4. Modern Drug Discovery - Medicinal Chemistry
5. Screening and Designing - Medicinal Chemistry
6. Nature as a Source of Drug Compounds - Medicinal Chemistry
7. Drug Designing - Medicinal Chemistry
SECTION I: PHYSICOCHEMICAL FACTORS IN RELATION TO BIOLOGICAL ACTIVITY OF DRUGS
Chapter 1: Physicochemical Properties
1. Physicochemical Properties - Medicinal Chemistry
Chapter 2: Ferguson Principle
1. Ferguson Principle - Medicinal Chemistry
Chapter 3: Hydrogen Bonding
1. Hydrogen Bonding - Medicinal Chemistry
2. Classification of Hydrogen Bonding - Medicinal Chemistry
Chapter 4: Ionization and pKa Value
1. Ionization and pKa Value - Medicinal Chemistry
Chapter 5: Redox Potential
Chapter 6: Surface Tension
1. Surface Tension - Medicinal Chemistry
2. Classification of Surface Tension - Medicinal Chemistry
Chapter 7: Complexation
1. Complexation - Medicinal Chemistry
Chapter 8: Steric Features of Drugs
1. Steric Features of Drugs - Medicinal Chemistry
Chapter 9: Bioisosterism
1. Bioisosterism - Medicinal Chemistry
2. Classification of Bioisosterism - Medicinal Chemistry
SECTION II: DRUG DESIGN
Chapter 1: Concepts of Drug Design
1. Concepts of Drug Design - Medicinal Chemistry
2. Design of Analogues and Prodrugs - Medicinal Chemistry
3. Design of Lead and Lead Discovery - Medicinal Chemistry
4. Rational Approach to Drug Design - Medicinal Chemistry
Chapter 2: Receptors
1. Receptors - Medicinal Chemistry
2. Types of Receptors - Medicinal Chemistry
3. Theories of Receptors - Medicinal Chemistry
4. Forces Involved in Drug Receptors Interaction - Medicinal Chemistry
5. Factors Affecting the Drug-Receptors Interaction - Medicinal Chemistry
Chapter 3: Computer-Aided Drug Design
1. Computer-Aided Drug Design - Medicinal Chemistry
2. Bioinformatics Hub - Advantages of CADD | Medicinal Chemistry
Chapter 4: Structure-Activity Relationship and Quantitative Structure Activity Relationship
1. Structure-Activity Relationship and Quantitative Structure Activity Relationship - Medicinal Chemistry
2. Historical Development of QSAR - Hansch Analysis, Free-Wilson Analysis | Quantitative Structure Activity Relationship | Medicinal Chemistry
3. Advantages and Disadvantages of QSAR - Quantitative Structure Activity Relationship | Medicinal Chemistry
4. Basic Requirements for QSAR Analysis - Quantitative Structure Activity Relationship | Medicinal Chemistry
5. Model Development Procedures - Quantitative Structure Activity Relationship | Medicinal Chemistry
Chapter 5: Combinatorial Chemistry
1. Combinatorial Chemistry - Principles | Medicinal Chemistry
2. Combinatorial Compound Libraries - Advantages, Disadvantages | Combinatorial Chemistry | Medicinal Chemistry
Chapter 6: Pro-Drugs
1. Pro-Drugs - Medicinal Chemistry
2. Classification of Pro-drugs - Medicinal Chemistry
3. Application of Pro-drugs - Medicinal Chemistry
SECTION III: DRUGS ACTING ON CENTRAL NERVOUS SYSTEM
Chapter 1: Central Nervous System
1. Central Nervous System - Drugs Acting on Central Nervous System | Medicinal Chemistry
Chapter 2: Sedatives and Hypnotics
1. Sedatives and Hypnotics - Drugs Acting on Central Nervous System | Medicinal Chemistry
2. Molecular Basis of Inhibitory Neurotransmitters - Drugs Acting on Central Nervous System | Medicinal Chemistry
3. Classification of Sedatives and Hypnotics - Drugs Acting on Central Nervous System | Medicinal Chemistry
4. Barbiturates - Structure, Properties, uses, Assay, Synthesis, Dose, Storage | Synthesis and Drug Profile | Sedatives and Hypnotics
5. SAR of Barbiturates - Sedatives and Hypnotics
6. Benzodiazepines - Structure, Properties, uses, Assay, Synthesis, Dose, Storage | Synthesis and Drug Profile | Sedatives and Hypnotics
7. SAR of Benzodiazepines - Synthesis and Drug Profile | Sedatives and Hypnotics
8. Acyclic hypnotics containing nitrogen - Structure, Properties, uses, Assay, Synthesis, Dose, Storage | Synthesis and Drug Profile | Sedatives and Hypnotics
9. Cyclic Hypnotics Containing Nitrogen - Structure, Properties, uses, Assay, Synthesis, Dose, Storage | Synthesis and Drug Profile | Sedatives and Hypnotics
10. Alcohols and Aldehydes - Structure, Properties, uses, Assay, Synthesis, Dose, Storage | Synthesis and Drug Profile | Sedatives and Hypnotics
11. Triclofos sodium - Structure, Properties, uses, Assay, Synthesis, Dose, Storage | Synthesis and Drug Profile | Sedatives and Hypnotics
12. Newer Agents - Structure, Properties, uses, Assay, Synthesis, Dose | Synthesis and Drug Profile | Sedatives and Hypnotics
Chapter 3: General Anaesthetics
1. General Anaesthetics and its types
2. Stages of Anaesthesia
3. Classification of General Anaesthetics
4. Volatile/Inhalation anaesthetics - Structure, Properties, uses, Synthesis, Metabolism, Storage | Synthesis and Drug Profile | General Anaesthetics
5. Nonvolatile or intravenous anaesthetics - Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms | Synthesis and Drug Profile | General Anaesthetics
Chapter 4: Local Anaesthetics
1. Local Anaesthetics - Drugs Acting on Central Nervous System
2. Classification of Local Anaesthetics
3. Benzoic acid derivatives - Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose | Synthesis and Drug Profile | Local Anaesthetics
4. Para amino benzoic acid derivatives - Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose | Synthesis and Drug Profile | Local Anaesthetics
5. SAR of Benzoic Acid Derivatives - Local Anaesthetics
6. Anilides - Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose | Synthesis and Drug Profile | Local Anaesthetics
7. SAR of Anilides - Local Anaesthetics
8. Miscellaneous class - Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose | Synthesis and Drug Profile | Local Anaesthetics
Chapter 5: Tranquillizers
1. Tranquillizers - Drugs Acting on Central Nervous System
2. General Mode of Action - Tranquillizers
3. Classification of Tranquillizers
4. Phenothiazines - Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose | Synthesis and Drug Profile | Tranquillizers
5. SAR of Phenothiazines - Tranquillizers
6. Benzodiazepines - Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose | Synthesis and Drug Profile | Tranquillizers
7. Fluoro butyrophenones - Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose | Synthesis and Drug Profile | Tranquillizers
8. SAR of Butyrophenones - Tranquillizers
9. Thioxanthines - Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose | Synthesis and Drug Profile | Tranquillizers
10. Dihydro indolones - Dihydro indolones | Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose | Synthesis and Drug Profile | Tranquillizers
11. Dibenzoxazepinones - Loxapine succinate (Loxapac) | Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose | Synthesis and Drug Profile | Tranquillizers
12. Dibenzodiazepines - Clozapine (Lozapin, Sizopin, Clopaz) | Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose | Synthesis and Drug Profile | Tranquillizers
13. Benzisoxazoles - Risperidone (Respidon, Sizodon, Rispid) | Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose | Synthesis and Drug Profile | Tranquillizers
14. Quetiapine (Placidin, Q-Pin, Pincalm) - Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose | Synthesis and Drug Profile | Tranquillizers
15. Ziprasidone (Azona, Zipsydon) - Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose | Synthesis and Drug Profile | Tranquillizers
16. Seretindole - Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose | Synthesis and Drug Profile | Tranquillizers
Chapter 6: Antidepressants
1. Antidepressants - Uses, Introduction
2. Classification of Antidepressants
3. Monoamine oxidase inhibitors (MAOIs) - Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose | Synthesis and Drug Profile | Antidepressants
4. Tricyclic antidepressants (TCAs) - Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose | Synthesis and Drug Profile | Antidepressants
5. SAR of Dibenzazepines - Antidepressants
6. Tricyclic antidepressants (TCAs) - Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose | Synthesis and Drug Profile | Antidepressants
7. SAR of Dibenzo Cycloheptane Derivatives - Antidepressants
8. Dibenzoxepine derivatives - Doxepin (Doxedep, Doxetar, Doxtin) | Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose | Synthesis and Drug Profile | Antidepressants
9. Selective Serotonin Reuptake Inhibitors (SSRIs) - Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose | Synthesis and Drug Profile | Antidepressants
10. Selective Norepinephrine Reuptake Inhibitors (SNERIs) - Venlafaxine | Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose | Synthesis and Drug Profile | Antidepressants
11. Bupropion, Trazodone - Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose | Synthesis and Drug Profile | Antidepressants
Chapter 7: CNS Stimulants
1. CNS Stimulants
2. Classification of CNS Stimulants
3. Respiratory stimulants - Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose | Synthesis and Drug Profile | CNS Stimulants
4. Psychomotor Stimulants - Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose | Synthesis and Drug Profile | CNS Stimulants
5. Xanthine Derivatives - Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose | Synthesis and Drug Profile | CNS Stimulants
6. Convulsant stimulants - Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose | Synthesis and Drug Profile | CNS Stimulants
7. Psychomimetic drugs - Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose | Synthesis and Drug Profile | CNS Stimulants
Chapter 8: Narcotic Analgesics
1. Narcotic Analgesics
2. Classification of Narcotic Analgesics
3. Morphine analogues - Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose | Synthesis and Drug Profile | Narcotic Analgesics
4. SAR of Morphine - Narcotic Analgesics
5. Meperidine analogues - Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose | Synthesis and Drug Profile | Narcotic Analgesics
6. SAR of Meperidine Analogues - Narcotic Analgesics
7. Methadone analogues - Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose | Synthesis and Drug Profile | Narcotic Analgesics
8. SAR of Diphenyl Heptanone (Methadone Series) - Narcotic Analgesics
9. Morphan derivatives - Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose | Synthesis and Drug Profile | Narcotic Analgesics
10. SAR of Benzomorphan Derivatives (Benzazocines) - Narcotic Analgesics
11. Miscellaneous - Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose | Synthesis and Drug Profile | Narcotic Analgesics
12. Narcotic antagonists
13. Classification of Narcotic antagonists
Chapter 9: Anticonvulsants
1. Anticonvulsants
2. Classification of Anticonvulsants
3. Barbiturates - Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose | Synthesis and Drug Profile | Anticonvulsants
4. SAR of Barbiturates
5. Hydantoins - Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose | Synthesis and Drug Profile | Anticonvulsants
6. SAR of Hydantoins - Anticonvulsants
7. Oxazolidinediones - Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose | Synthesis and Drug Profile | Anticonvulsants
8. SAR of Oxazolidinediones - Anticonvulsants
9. Succinimides - Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose | Synthesis and Drug Profile | Anticonvulsants
10. SAR of Succinimides - Anticonvulsants
11. Phenyl acetyl urea derivatives - Phenacemide (Phenurone) | Structure, uses, Synthesis, Dose | Synthesis and Drug Profile | Anticonvulsants
12. SAR of Phenacemide - Anticonvulsants
13. Benzodiazepines - Clobazam | Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose | Synthesis and Drug Profile | Anticonvulsants
14. GABA analogues - Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose | Synthesis and Drug Profile | Anticonvulsants
15. Iminostilbenes - Carbamazepine | Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose | Synthesis and Drug Profile | Anticonvulsants
16. Sodium Valproate - (Epilex, Epival, Valparin) | Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose | Synthesis and Drug Profile | Anticonvulsants
17. SAR of Sodium Valproate - Anticonvulsants
18. Newer anticonvulsants - Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose | Synthesis and Drug Profile | Anticonvulsants
Chapter 10: Antiparkinsonism Agents
1. Antiparkinsonism Agents
2. Classification of Antiparkinsonism Agents
3. Drugs affecting brain dopamine - Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose | Synthesis and Drug Profile | Antiparkinsonism Agents
4. Anticholinergic agents - Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose | Synthesis and Drug Profile | Antiparkinsonism Agents
Chapter 11: Skeletal Muscle Relaxants
1. Skeletal Muscle Relaxants
2. Classification of Skeletal Muscle Relaxants
3. Neuromuscular blocking agents - Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose | Synthesis and Drug Profile | Skeletal Muscle Relaxants
4. Centrally Acting Muscle Relaxants - Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose | Synthesis and Drug Profile | Skeletal Muscle Relaxants
Chapter 12: Alzheimer s Disease
1. Alzheimer’s Disease
2. Pathogenesis - Alzheimer’s Disease
3. Treatment of Alzheimer’s Disease
SECTION IV: DRUGS ACTING ON AUTONOMIC NERVOUS SYSTEM
Chapter 1: Autonomic Nervous System
1. Autonomic Nervous System
Chapter 2: Adrenergic Drugs
1. Adrenergic Drugs
2. Physiological Basis of Adrenergic Receptors Function
3. General Classification of Adrenergic Agonists
4. Catecholamines - Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose | Synthesis and Drug Profile | Adrenergic Drugs
5. Noncatecholamines - Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose | Synthesis and Drug Profile | Adrenergic Drugs
6. Structure Activity Relationship - Adrenergic Drugs
Chapter 3: Cholinergic Drugs
1. Cholinergic Drugs
2. Spectrum of Cholinomimetic Drugs
3. Classification of Cholinergic Drugs
4. Direct-acting cholinergic drugs - Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose | Synthesis and Drug Profile | Cholinergic Drugs
5. Indirectly acting cholinergic drugs - Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose | Synthesis and Drug Profile | Cholinergic Drugs
6. Structural Activity Relationship - Cholinergic Drugs
Chapter 4: Adrenergic Blockers
1. Adrenergic Blockers
2. Physiological Basis of Adrenergic Receptor
3. Classification of Adrenergic Blockers
4. Alpha-receptor Adrenergic blocking agents - Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose | Synthesis and Drug Profile | Adrenergic Blockers
5. Beta receptor Adrenergic blocking agents - Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose | Synthesis and Drug Profile | Adrenergic Blockers
6. Structure Activity Relationship - Adrenergic Blockers
Chapter 5: Anticholinergic Drugs
1. Anticholinergic Drugs
2. Difference Between the Quaternary and the Tertiary Antimuscarinics
3. Classification of Anticholinergic Drugs
4. Solanaceous alkaloids and analogues - Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose | Synthesis and Drug Profile | Anticholinergic Drugs
5. SAR Solanaceous Alkaloids (Atropine Analogues) - Anticholinergic Drugs
6. Amino alcohol esters - Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose | Synthesis and Drug Profile | Anticholinergic Drugs
7. Amino ethers - Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose | Synthesis and Drug Profile | Anticholinergic Drugs
8. Amino Alcohol - Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose | Synthesis and Drug Profile | Anticholinergic Drugs
9. Amino Amides - Tropicamide | Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose | Synthesis and Drug Profile | Anticholinergic Drugs
10. SAR of Muscarinic Antagonists - Anticholinergic Drugs
SECTION V: DRUGS ACTING ON CARDIOVASCULAR SYSTEM
Chapter 1: Cardiovascular System
1. Cardiovascular System
Chapter 2: Antihypertensive Drugs
1. Antihypertensive Drugs
2. Classification of Antihypertensive Drugs
3. Drugs acting on renin-angiotensin system - Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose | Synthesis and Drug Profile | Antihypertensive Drugs
4. Angiotensin II Antagonist - Structure, Properties, uses, Synthesis | Synthesis and Drug Profile | Antihypertensive Drugs
5. Vasodilators - Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose | Synthesis and Drug Profile | Antihypertensive Drugs
Chapter 3: Antiarrhythmic Drugs
1. Antiarrhythmic Drugs
2. Classification of Antiarrhythmic Drugs
3. Moderate to marked sodium channel blockade agents - Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose | Synthesis and Drug Profile | Antiarrhythmic Drugs
4. Mild-to-moderate sodium channel blockers - Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose | Synthesis and Drug Profile | Antiarrhythmic Drugs
5. Marked sodium channel blockers - Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose | Synthesis and Drug Profile | Antiarrhythmic Drugs
6. β-Adrenergic Receptor Blockers - Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose | Synthesis and Drug Profile | Antiarrhythmic Drugs
7. Repolarization Prolongers - Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose | Synthesis and Drug Profile | Antiarrhythmic Drugs
8. Calcium Channel Blockers - Dose | Antiarrhythmic Drugs
Chapter 4: Antihyperlipidaemic Agents
1. Antihyperlipidaemic Agents
2. Classification of Antihyperlipidaemic Agents
3. HMG CoA-Reductase Inhibitors - Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose | Synthesis and Drug Profile | Antihyperlipidaemic Agents
4. Fibric acid derivatives - Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose | Synthesis and Drug Profile | Antihyperlipidaemic Agents
5. Bile acid sequestrants - Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose | Synthesis and Drug Profile | Antihyperlipidaemic Agents
6. LDL Oxidation Inhibitors - Probucol (Lorelco) | Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose | Synthesis and Drug Profile | Antihyperlipidaemic Agents
7. Pyridine derivatives - Nicotinic acid | Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose | Synthesis and Drug Profile | Antihyperlipidaemic Agents
8. Miscellaneous Agents - Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose | Synthesis and Drug Profile | Antihyperlipidaemic Agents
Chapter 5: Antianginals
1. Antianginals
2. Principles of Therapy for Angina
3. Classification of Antianginals
4. Nitrites and Nitrates - Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose | Synthesis and Drug Profile | Antianginals
5. β-Adrenergic blocking agents - Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose | Synthesis and Drug Profile | Antianginals
6. Calcium channel blockers - Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose | Synthesis and Drug Profile | Antianginals
7. SAR of Dihydropyridines - Antianginals
8. Dihydropyridines - Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose | Synthesis and Drug Profile | Antianginals
9. Second-Generation Alkyl Amine Type Calcium Channel Blockers - Bepridil | Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose | Synthesis and Drug Profile | Antianginals
10. Cardiovascular agents - Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose | Synthesis and Drug Profile | Antianginals
11. Dipyridamole - Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose | Synthesis and Drug Profile | Antianginals
SECTION VI: DRUGS ACTING ON URINARY SYSTEM
Chapter 1: Urinary System
1. Urinary System
2. Functions of Renal System
Chapter 2: Diuretics
1. Diuretics
2. Classification of Diuretics
3. Mercurial diuretics - Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose | Synthesis and Drug Profile | Diuretics
4. Thiazides - Nonmercurial diuretics - Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose | Synthesis and Drug Profile | Diuretics
5. Hydrothiazides - Nonmercurial diuretics - Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose | Synthesis and Drug Profile | Diuretics
6. SAR of Thiazide Diruretics
7. CAse inhibitors - Nonmercurial diuretics - Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose | Synthesis and Drug Profile | Diuretics
8. SAR of CAse Inhibitiors
9. Sulphonamide derivatives - Nonmercurial diuretics - Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose | Synthesis and Drug Profile | Diuretics
10. Aldosterone antagonists - Nonmercurial diuretics - Spironolactone (Aldactone) | Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose | Synthesis and Drug Profile | Diuretics
11. Potassium sparing diuretics - Nonmercurial diuretics - Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose | Synthesis and Drug Profile | Diuretics
12. High ceiling or Loop diuretics - Nonmercurial diuretics - Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose | Synthesis and Drug Profile | Diuretics
13. SAR of Loop Diuretics
14. Phenoxyacetic acid derivatives - Nonmercurial diuretics - Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose | Synthesis and Drug Profile | Diuretics
15. Xanthine diuretics - Nonmercurial diuretics
16. Osmotic diuretics - Nonmercurial diuretics - Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose | Synthesis and Drug Profile | Diuretics
17. Acidifying salts - Nonmercurial diuretics
SECTION VII: DRUGS ACTING ON INFLAMMATION/ALLERGY
Chapter 1: Antihistamines
1. Antihistamines
2. Structure–Activity Relationship-H1 Receptor - Antihistamines
3. Classification of Antihistamines
4. Ethylene diamine derivatives - H1-antagonists with classical structure | Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose | Synthesis and Drug Profile | Antihistamines
5. Amino alkyl ether analogues - H1-antagonists with classical structure | Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose | Synthesis and Drug Profile | Antihistamines
6. Piperazines derivatives - Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose | Synthesis and Drug Profile | Antihistamines
7. Monoamino propylamine derivatives - Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose | Synthesis and Drug Profile | Antihistamines
8. Monoaminopropyl analogues - Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose | Synthesis and Drug Profile | Antihistamines
9. Tricyclic ring system or phenothiazines - Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose | Synthesis and Drug Profile | Antihistamines
10. Dibenzocyclo heptene derivatives - Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose | Synthesis and Drug Profile | Antihistamines
11. Antazoline (Antistine) - Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose | Synthesis and Drug Profile | Antihistamines
12. Ketotifen Fumarate (Zaditen) - Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose | Synthesis and Drug Profile | Antihistamines
13. H1-Antagonists with nonclassical structure - Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose | Synthesis and Drug Profile | Antihistamines
14. Nonsedative H1-antihistamines (H1-antagonists) - Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose | Synthesis and Drug Profile | Antihistamines
15. Inhibition of histamine release (mast cell stabilizer)
Chapter 2: Prostaglandins
1. Prostaglandins
2. Functions of PGs (Prostaglandins)
3. Biosynthesis - Prostaglandins
4. Prostaglandins - Synthesis and Drug Profile - Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose | Synthesis and Drug Profile | Prostaglandins
Chapter 3: Analgesics, Antipyretics, and NSAIDs
1. Analgesics, Antipyretics, and NSAIDs
2. Classification - Analgesics, Antipyretics, and NSAIDs
3. Salicylates - Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose | Synthesis and Drug Profile
4. p-Amino phenol derivatives - SAR, Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose | Synthesis and Drug Profile
5. 3, 5-Pyrazolidinediones - SAR, Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose | Synthesis and Drug Profile
6. Anthranilic acid derivatives (Fenamates) - SAR, Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose | Synthesis and Drug Profile
7. Arylalkanoic acids - SAR, Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose | Synthesis and Drug Profile
8. Oxicams - SAR, Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose | Synthesis and Drug Profile
9. Selective COX-2 inhibitor - SAR, Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose | Synthesis and Drug Profile
10. Miscellaneous - Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose | Synthesis and Drug Profile
11. Drugs used in the treatment of gout - Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose | Synthesis and Drug Profile
SECTION VIII: DRUGS ACTING ON RESPIRATORY SYSTEM
Chapter 1: Expectorants and Antitussives
1. Introduction to Respiratory System - Expectorants and Antitussives
2. Expectorants and Antitussives - Expectorants and Antitussives
3. Classification of Expectorants and Antitussives
4. Centrally acting antitussive agents - Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose | Synthesis and Drug Profile
5. Peripherally acting antitussives - Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose | Synthesis and Drug Profile
SECTION IX: DRUGS ACTING ON DIGESTIVE SYSTEM
Chapter 1: Antiulcer Agents
1. Classification of Antiulcer Agents
2. H2-receptor antagonists - Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose | Synthesis and Drug Profile | Antiulcer Agents
3. SAR of H2-receptor Antagonists - Antiulcer Agents
4. Proton pump inhibitors - Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose | Synthesis and Drug Profile | Antiulcer Agents
Chapter 2: Antidiarrhoeals
1. Antidiarrhoeals - Drugs Acting on Digestive System
2. Antidiarrhoeals: Adsorbents - Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose | Synthesis and Drug Profile
3. Antisecretory drugs - Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose | Synthesis and Drug Profile | Antidiarrhoeals
SECTION X: DRUGS ACTING ON BLOOD AND BLOOD-FORMING ORGANS
Chapter 1: Coagulants
1. Coagulants - Drugs Acting on Blood and Blood-Forming Organs
2. Classification of Coagulants
3. In vitro anticoagulants - Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose | Synthesis and Drug Profile | Coagulants
4. In vivo anticoagulants or coumarin derivatives - Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose | Synthesis and Drug Profile | Coagulants
5. Indanedione derivatives-General method of preparation - Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose | Synthesis and Drug Profile | Coagulants
6. Antiplatelet drugs (Antithrobocytic drugs) - Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose | Synthesis and Drug Profile | Coagulants
Chapter 2: Plasma Expanders
1. Plasma Expanders
SECTION XI: Drugs Acting on Endocrine System
Chapter 1: Oral Hypogylcaemic Drugs
1. Oral Hypogylcaemic Drugs
2. Classification of Oral Hypogylcaemic Drugs
3. Sulphonylurea derivatives - Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose | Synthesis and Drug Profile | Oral Hypogylcaemic Drugs
4. SAR of Sulphonylureas
5. Biguanides - Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose | Synthesis and Drug Profile | Oral Hypogylcaemic Drugs
6. Meglitinides (Benzoic acid derivatives) - Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose | Synthesis and Drug Profile | Oral Hypogylcaemic Drugs
7. Thiazolidinediones - Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose | Synthesis and Drug Profile | Oral Hypogylcaemic Drugs
8. Aldose reducatse inhibitors - Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose | Synthesis and Drug Profile | Oral Hypogylcaemic Drugs
9. Linogliride - Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose | Synthesis and Drug Profile | Oral Hypogylcaemic Drugs
Chapter 2: Steroids
1. Steroids - Drugs Acting on Endocrine System
2. Steroid Nomenclature and Structure
3. Adrenal cortex - Classification, Structure, Properties, uses, Synthesis, Storage, Dose | Synthesis and Drug Profile | Steroids
4. Progestogens - Classification, Structure, Properties, uses, Synthesis, Storage, Dose | Synthesis and Drug Profile | Steroids
5. Oestrogens - Classification, Structure, Properties, uses, Synthesis, Storage, Dose | Synthesis and Drug Profile | Steroids
6. Androgens and Anabolic Agents - Classification, Structure, Properties, uses, Synthesis, Storage, Dose | Synthesis and Drug Profile | Steroids
Chapter 3: Antithyroid Drugs
1. Antithyroid Drugs - Drugs Acting on Endocrine System
2. Classification of Antithyroid Drugs
3. Antithyroid Drugs: Thioureylenes - Synthesis and Drug Profile - Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose
SECTION XII: CHEMOTHERAPY
Chapter 1: History and Development of Chemotherapy
1. History and Development of Chemotherapy
2. Spectrum of Activity of Chemotherapeutic Agents
Chapter 2: Antibacterial Sulphonamides
1. Antibacterial Sulphonamides - Chemotherapy
2. SAR of Sulphonamides - Chemotherapy
3. Classification of Sulphonamides
4. N-1 Substituted sulphonamides - Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose | Synthesis and Drug Profile | Antibacterial Sulphonamides
5. Both N-1 and N-4 substituted sulphonamides - Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose | Synthesis and Drug Profile | Antibacterial Sulphonamides
6. Topically used sulphonamides - Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose | Synthesis and Drug Profile | Antibacterial Sulphonamides
7. Drugs used in combination with sulphonamides - Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose | Synthesis and Drug Profile | Antibacterial Sulphonamides
Chapter 3: Quinolone Antibacterials
1. Quinolone Antibacterials - Chemotherapy
2. Effective Antibacterial Quinolone Derivatives
3. Quinolone: Synthesis and Drug Profile - Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose | Quinolone Antibacterials
4. SAR of Quinolones
Chapter 4: Antibiotics
1. Antibiotics - Chemotherapy
2. Classification of Antibiotics
3. Classification of penicillins - Antibiotics
4. SAR of Penicillins
5. Penicillinase resistant penicillins - Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose | Synthesis and Drug Profile | penicillin
6. Penicillinase Susceptible Penicillins - Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose | Synthesis and Drug Profile | penicillin
7. Amino penicillins - Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose | Synthesis and Drug Profile | penicillin
8. Antipseudomonal penicillins - Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose | Synthesis and Drug Profile | penicillin
9. Ureido penicillins - Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose | Synthesis and Drug Profile | penicillin
10. Mecillinam (Amdinocillin) - Structure, Properties, uses, Synthesis | Synthesis and Drug Profile | penicillin
11. Cephalosporins
12. Generalized formula for cephalosporins
13. Classification of Cephalosporins
14. Degradation of Cephalosporins
15. SAR of Cephalosporins
16. 7-Aminocephalosporinic acid (7ACA) - Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose | Synthesis and Drug Profile | Cephalosporins
17. First-generation cephalosporins - Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose | Synthesis and Drug Profile | Cephalosporins
18. Second-generation cephalosporin - Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose | Synthesis and Drug Profile | Cephalosporins
19. Third-generation cephalosporins - Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose | Synthesis and Drug Profile | Cephalosporins
20. Fourth-generation cephalosporin - Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose | Synthesis and Drug Profile | Cephalosporins
21. Miscellaneous - Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose | Synthesis and Drug Profile | Cephalosporins
22. Aminoglycoside antibiotics
23. SAR of Aminoglycoside Antibiotics
24. Structural features of aminoglycoside antibiotics
25. Tetracycline antibiotics
26. Classes of tetracyclines antibiotics
27. SAR of Tetracyclines
28. Polypeptide antibiotics
29. Macrolide antibiotics
30. Lincomycins
31. Other antibiotics
Chapter 5: Antitubercular Agents
1. Antitubercular Agents
2. Antitubercular Agents : Standard drugs - Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose | Synthesis and Drug Profile
3. Antitubercular Agents : Reserve drugs - Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose | Synthesis and Drug Profile
Chapter 6: Antifungal Agents
1. Antifungal Agents
2. Classification of Antifungal Agents
3. Antibiotics - Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose | Synthesis and Drug Profile | Antifungal Agents
4. Azole antifungals
5. Fluorinated pyrimidines - Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose | Synthesis and Drug Profile | Antifungal Agents
6. Chitin synthetase inhibitors - Nikomycin | Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose | Synthesis and Drug Profile | Antifungal Agents
7. Peptides\proteins - Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose | Synthesis and Drug Profile | Antifungal Agents
8. Miscellaneous agents - Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose | Synthesis and Drug Profile | Antifungal Agents
Chapter 7: Antiviral Agents
1. Antiviral Agents
2. Classification of Antiviral Agents
3. Nucleotide analogues - Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose | Synthesis and Drug Profile | Antiviral Agents
4. Non-nucleoside RT inhibitors - Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose | Synthesis and Drug Profile | Antiviral Agents
5. Anti-HIV agents - Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose | Synthesis and Drug Profile | Antiviral Agents
6. SAR of Adamantane Amines
Chapter 8: Antiamoebic Agents
1. Antiamoebic Agents
2. Classification of Amoebicides
3. Luminal amoebicdes - Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose | Synthesis and Drug Profile | Antiamoebic Agents
4. Mixed amoebicdes - Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose | Synthesis and Drug Profile | Antiamoebic Agents
Chapter 9: Antimalarials
1. Antimalarials
2. Life Cycle of Plasmodium - Antimalarials
3. Classification of Antimalarials
4. 4-Substituted Quinolines - Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose | Synthesis and Drug Profile | Antimalarials
5. 4-Substituted Quinolines: Structure Activity Relationship - Antimalarials
6. 8-Amino quinolines
7. Acridine Derivatives - Structure, Properties, uses, Synthesis | Synthesis and Drug Profile | Antimalarials
8. Biguanides and Diaminopyrimidines - Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose | Synthesis and Drug Profile | Antimalarials
9. Sulphones and sulphonamides - Synthesis and Drug Profile | Antimalarials
10. Micellaneous - Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose | Synthesis and Drug Profile | Antimalarials
Chapter 10: Anthelmintics
1. Anthelmintics
2. Classification of Anthelmintics
3. Benzimidazoles - Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose | Synthesis and Drug Profile | Anthelmintics
4. Quinoline and isoquinolines - Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose | Synthesis and Drug Profile | Anthelmintics
5. Piperazine derivatives - Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose | Synthesis and Drug Profile | Anthelmintics
6. Vinyl pyrimidines - Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose | Synthesis and Drug Profile | Anthelmintics
7. Amides - Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose | Synthesis and Drug Profile | Anthelmintics
8. Natural products - Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose | Synthesis and Drug Profile | Anthelmintics
9. Organophosphorus compounds - Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose | Synthesis and Drug Profile | Anthelmintics
10. Midazothiazoles - Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose | Synthesis and Drug Profile | Anthelmintics
11. Nitro derivatives - Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose | Synthesis and Drug Profile | Anthelmintics
Chapter 11: Antineoplastic Agents
1. Antineoplastic Agents
2. Classification of Antineoplastic Agents
3. Alkylating agents - Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose | Synthesis and Drug Profile | Antineoplastic Agents
4. Antimetabolites - Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose | Synthesis and Drug Profile | Antineoplastic Agents
5. Antibiotics - Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose | Synthesis and Drug Profile | Antineoplastic Agents
6. Plant products - Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose | Synthesis and Drug Profile | Antineoplastic Agents
7. Enzymes - Synthesis and Drug Profile | Antineoplastic Agents
8. Hormones - Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose | Synthesis and Drug Profile | Antineoplastic Agents
9. Immunotherapy - Antineoplastic Agents
10. Micellaneous - Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose | Synthesis and Drug Profile | Antineoplastic Agents
Chapter 12: Antileprotic Drugs
1. Antileprotic Drugs
2. Classification of Antileprotic Drugs
3. Sulphones - Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose | Synthesis and Drug Profile | Antileprotic Drugs
4. Benzpyrazine derivatives - Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose | Synthesis and Drug Profile | Antileprotic Drugs
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