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Biopharmaceutics and Pharmacokinetics - Online Course


Biopharmaceutics and Pharmacokinetics - Pharmacy Department



Biopharmaceutics and Pharmacokinetics




Chapter 1: Introduction


1. Biopharmaceutics and Pharmacokinetics



Chapter 2: Absorption of Drugs


1. Absorption of Drugs - Biopharmaceutics and Pharmacokinetics
2. Gastrointestinal Absorption of Drugs
3. Mechanisms of Drug Absorption - Biopharmaceutics and Pharmacokinetics
4. Factors Influencing Drug Absorption and Bioavailability - Biopharmaceutics and Pharmacokinetics
5. Pharmaceutical Factors
6. Physicochemical Factors Affecting Drug Absorption
7. Dosage Form (Pharmaco-Technical) Factors
8. Gastrointestinal tract - Absorption of Drugs
9. Patient Related Factors Affecting Drug Absorption
10. Methods for Studying Drug Uptake - Absorption of Drugs
11. Absorption of Drugs From Non-PER OS Extravascular Routes



Chapter 3: Distribution of Drugs


1. Distribution of Drugs
2. Tissue Permeability of Drugs - Distribution of Drugs
3. Organ/Tissue Size and Perfusion Rate - Distribution of Drugs
4. Binding of Drugs to Tissue Components - Distribution of Drugs
5. Miscellaneous Factors Affecting Drug Distribution
6. Volume of Distribution - Distribution of Drugs



Chapter 4: Protein Binding of Drugs


1. Mechanisms of Protein-Drug Binding
2. Binding of Drugs to Blood Components - Protein Binding of Drugs
3. Tissue Binding of Drugs (Tissue Localization of Drugs) - Protein Binding of Drugs
4. Determination of Protein-Drug Binding
5. Factors Affecting Protein-Drug Binding
6. Drug Related Factors - Protein Binding of Drugs
7. Protein/Tissue Related Factors - Protein Binding of Drugs
8. Drug Interactions - Protein Binding of Drugs
9. Patient Related Factors - Protein Binding of Drugs
10. Significance of Protein/Tissue Binding of Drugs
11. Kinetics of Protein-Drug Binding



Chapter 5: Biotransformation of Drugs


1. Biotransformation of Drugs
2. Chemical Pathways of Drug Biotransformation
3. Oxidative Reactions - Biotransformation of Drugs
4. Reductive Reactions - Biotransformation of Drugs
5. Hydrolytic Reactions - Biotransformation of Drugs
6. Phase II Reactions - Biotransformation of Drugs
7. Conjugation With Glucuronic Acid - Biotransformation of Drugs
8. Conjugation With Sulphate Moieties - Biotransformation of Drugs
9. Conjugation With Alpha Amino Acids - Biotransformation of Drugs
10. Conjugation With Glutathione and Mercapturic Acid Formation - Biotransformation of Drugs
11. Acetylation - Biotransformation of Drugs
12. Methylation - Biotransformation of Drugs
13. Miscellaneous Conjugation Reactions - Biotransformation of Drugs
14. Methods for the Study of Drug Biotransformation
15. Factors Affecting Biotransformation of Drugs
16. Physicochemical Properties of the Drug
17. Chemical factors of Drug
18. Biological Factors of Drug
19. Bioactivation and Tissue Toxicity - Biotransformation of Drugs



Chapter 6: Excretion of Drugs


1. Excretion of Drugs
2. Renal Excretion of Drugs
3. Concept of Clearance - Excretion of Drugs
4. Factors Affecting Renal Excretion or Renal Clearance
5. Renal Function and Renal Failure - Excretion of Drugs
6. Non-Renal Routes of Drug Excretion



Chapter 7: Pharmacokinetic Drug Interactions


1. Pharmacokinetic Drug Interactions
2. Factors Contributing to Drug Interactions
3. Mechanisms of Pharmacokinetic Drug Interactions
4. Interactions Affecting Absorption, Distribution, Metabolism, Excretion of Drugs



Chapter 8: Pharmacokinetics Basic Considerations


1. Pharmacokinetics: Basic Considerations
2. Plasma Drug Concentration-Time Profile
3. Pharmacokinetic Parameters
4. Pharmacodynamic Parameters
5. Rate, Rate Constants and Orders of Reactions - Pharmacokinetics
6. Zero-Order Kinetics (Constant Rate Processes) - Pharmacokinetics
7. Zero-Order Half-Life - Pharmacokinetics
8. First-Order Kinetics (Linear Kinetics) - Pharmacokinetics
9. First-Order Half-Life - Pharmacokinetics
10. Mixed-Order Kinetics (Nonlinear Kinetics) - Pharmacokinetics
11. Pharmacokinetic Parameters/Variables
12. Various approaches used for quantitative study of kinetic processes - Pharmacokinetics



Chapter 9: Compartment Modelling


1. Compartment Modelling - Pharmacokinetics
2. One-Compartment Open Model (Instantaneous Distribution Model) - Compartment Modelling
3. One-Compartment Open Model : Intravenous Bolus Administration - Compartment Modelling
4. One-Compartment Open Model: Intravenous Infusion - Compartment Modelling
5. One-Compartment Open Model: Extravascular Administration - Compartment Modelling
6. Urinary Excretion Data (Disposition Viewed from Urine only) - Compartment Modelling
7. Multicompartment Models (Delayed Distribution Models) - Compartment Modelling
8. Two-Compartment Open Model - Compartment Modelling
9. Two-Compartment Open Model: Intravenous Bolus Administration - Compartment Modelling
10. Two-Compartment Open Model: Intravenous Infusion - Compartment Modelling
11. Two-Compartment Open Model: Extravascular Administration - First-Order Absorption - Compartment Modelling



Chapter 10: Nonlinear Pharmacokinetics


1. Nonlinear Pharmacokinetics
2. Causes of Nonlinearity - Nonlinear Pharmacokinetics
3. Michaelis Menten Equation - Nonlinear Pharmacokinetics



Chapter 11: Bioavailability and Bioequivalence


1. Bioavailability and Bioequivalence
2. Considerations In In-Vivo Bioavailability Study Design
3. Bioequivalence Studies - Biopharmaceutics and Pharmacokinetics
4. Methods For Enhancement of Bioavailability
5. Bioavailability Enhancement Through Enhancement of Drug Solubility or Dissolution Rate
6. Bioavailability Enhancement Through Enhancement of Drug Permeability Across Biomembrane
7. Bioavailability Enhancement Through Enhancement of Drug Stability
8. Bioavailability Enhancement Through Gastrointestinal Retention
9. Applications of Pharmacokinetic Principles
10. Design of Dosage Regimens
11. Individualization - Bioavailability and Bioequivalence
12. Monitoring Drug Therapy



Chapter 12: Drug Concentration and Pharmacological Response


1. Drug Concentration and Pharmacological Response
2. Problems in Developing PK/PD Relationship
3. Concentration-Response Relationships - Pharmacodynamic Models
4. Onset/Duration of Effect-Concentration Relationships
5. Intensity of Effect-Concentration Relationships



Chapter 13: Controlled Release Medication


1. Controlled Release Medication - Biopharmaceutics and Pharmacokinetics
2. Factors in the Design of Controlled-Release Drug Delivery Systems
3. Pharmacokinetic Principles in the Design and Fabrication of Controlled-Release Drug Delivery Systems
4. Drug Release Patterns of Controlled Delivery Dosage Forms
5. Classification of CRDDS - Controlled Release Medication
6. Oral Controlled Release Systems
7. Parenteral Controlled Release Systems
8. Transdermal Drug Delivery Systems
9. Ophthalmic Drug Delivery Systems
10. Intravaginal & Intrauterine Drug Delivery Systems
11. Bioavailability Testing of Controlled Release Formulations




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