Essential Clinical Immunology
Basic Components of the Immune System
1. Basic Components of the Immune System
2. Antigens
3. Antibody
4. T Cells and their Receptors
5. Major Histocompatibility Complex
6. Adhesion Molecules
7. Cytokines
8. Initiation of the Immune Response
9. Antibody Production
10. Functional Components of the Immune System
11. Tissue Damage Pathways: Hypersensitivity Reactions
Immunological Techniques
1. Antibody Production
2. Immunological Assays
3. Lymphocytic Assays
4. Fluorescein-Activated Cell Sorter
5. Lymphocyte Proliferation Assays
6. DNA Technology Assays
Immune Regulation
1. Immuno suppression: Immunosuppressive Drugs
2. Antibodies and Other Immunosuppressive Methods
3. Immunopotentiation
4. Cytokine Immunomodulation
5. Cellular Vaccines and Modulations There of Dendritic Cell Vaccines
Immunological Aspects of Infection
1. Non Specific Resistance - Immunological Aspects of Infection
2. Adaptive Immunity
3. Bacterial Infection
4. Bacterial Superantigens
5. Bacterial Evasion of Immune Defense
6. Viral Infections
7. Fungal Infection
8. Parasitic Infection
Immunological Aspects of Immunodeficiency Diseases
1. Immunological Aspects of Immunodeficiency Diseases
2. Defects in Anatomical or Physiological Barriers to Infection
3. Disorders Characterized By Antibody Deficiency
4. Clinical Manifestations of Antibody Deficiency
5. Major Categories of Antibody Deficiency
6. Defects in Cell-Mediated Immunity (T-Cell Dependent Immunity)
7. Manifestations of T-Cell Deficiency
8. Major Categories of Combined Immunodeficiency
9. Immunological and Molecular Classification of SCID
10. Treatment of SCID
11. DiGeorge�s Syndrome (Thymic Aplasia)
12. Phagocyte Deficiencies
13. Neutropenia - Phagocyte Deficiencies
14. Defects in Leucocyte Migration - Phagocyte Deficiencies
15. Defects in Bacterial Killing - Phagocyte Deficiencies
16. Defects in Killing of Intracellular Bacteria by Activated Macrophages
17. Complex Immunodeficiencies Due to Miscellaneous Defects
18. Immunodeficiencies Resulting in Defective Homeostasis of the Immune System
19. Defects in the Cytolytic Pathway
20. Inherited Deficiency of the Complement System
21. Defects in Innate Immunity
Autoimmunity
1. Definitions and Types of Autoimmunity
2. Type II Autoimmune Reactions - Mechanisms of Autoimmune Tissue Injury and Examples
3. Type IIA Autoimmune Reaction: Autoimmune Hemolytic Anemia - Mechanisms of Autoimmune Tissue Injury and Examples
4. Type IIB Hypersensitivity: Graves� Disease - Mechanisms of Autoimmune Tissue Injury and Examples
5. Type IIB Hypersensitivity: Myasthenia Gravis - Mechanisms of Autoimmune Tissue Injury and Examples
6. Type III Autoimmune Reactions (Immune Complex Disease) - Mechanisms of Autoimmune Tissue Injury
7. Type IV Autoimmune Reactions (T-Cell Mediated) - Mechanisms of Autoimmune Tissue Injury and Examples
8. Epidemiology of Autoimmune Disease
9. Animal Models of Autoimmune Disease
10. SLE (NZB X NZW F1, MRL, BXSB, TMPD)
11. Rheumatoid Arthritis (Collagen-Induced Arthritis, TTP Deficiency, K/BxN Model)
12. Multiple Sclerosis (Experimental Autoimmune Encephalomyelitis)
13. Type I Diabetes (Nonobese Diabetic Mouse Model)
14. Autoimmune Thyroiditis (Experimental Autoimmune Thyroiditis)
15. Pathogenesis of Autoimmune Disease
16. Treatment of Autoimmune Disease
Chronic Lymphocytic Leukemia
1. B-Cell Activation and Maturation
2. Characterizing the Heterogeneity of B-CLL by Molecular and Clinical Subtypes
3. Development of B-CLL From Normal B Lymphocytes
4. Correlations Between the Cellular and Molecular Features of the Disease With the Clinical Course of B-CLL
5. Summary Remarks on the Development, Growth, and Evolution of B-CLL
6. Animal Models of B-CLL
7. Clinical Implications and the Development of Novel Therapeutics
Immunology of HIV Infections
1. Immunological and Biological Parameters of Disease
2. Animal Models of HIV Infection
3. Vaccines to Prevent HIV Infection
4. Vaccine Candidates - Immunology of HIV Infections
Immunological Aspects of Allergy and Anaphylaxis
1. Immunological Aspects of Allergy and Anaphylaxis
2. Allergic Hypersensitivity
3. Atopy
4. Systemic Anaphylaxis and Anaphylactoid Reactions
5. Allergic Conjunctivitis
6. Allergic Disease of the Respiratory Tract
7. Allergic Rhinitis: Overview, Clinical Disease States, Experimental Models
8. Allergic Asthma: Overview, Immunology, Experimental Models
9. Food Allergy and Intolerance: Diagnosis, Food Intolerance
10. Skin Diseases and Allergy
Immunological Aspects of Skin Diseases
1. Immunological Aspects of Skin Diseases
2. Psoriasis - Skin Diseases
3. Alopecia Areata
4. Antibody Induced Bullous Skin Lesions
Experimental Approaches to the Study of Autoimmune Rheumatic Diseases
1. Experimental Approaches to the Study of Autoimmune Rheumatic Diseases
2. Types of Animal Models
3. Rheumatoid Arthritis: Etiology, Pathogenesis, Clinical Features, Treatment
4. Animal Models of Rheumatoid Arthritis
5. Systemic Lupus Erythematosus: Epidemiology, Etiology, Pathogenesis, Clinical Features, Treatment
6. Animal Models of Systemic Lupus Erythematosus(SLE)
7. Sjogren�s Syndrome: Epidemiology, Etiology, Pathogenesis, Clinical Features, Treatment, Animal Models
8. Progressive Systemic Sclerosis: Epidemiology, Etiology, Pathogenesis, Clinical Features, Treatment, Animal Models
9. Polymyositis: Epidemiology, Etiology, Pathogenesis, Clinical Features, Treatment, Animal Models
10. Seronegative Spondyloarthropathy: Epidemiology, Etiology, Pathogenesis, Clinical Features, Treatment, Animal Models
Immunological Aspects of Cardiac Disease
1. Rheumatic Fever
2. Epidemiology and Pathogenesis of Rheumatic Fever
3. Rheumatic Fever: Genetics
4. Etiologic Considerations of Rheumatic Fever
5. Animal Models of Rheumatic Fever
6. Streptococcal Vaccine Candidate
7. Chagas� Disease
8. Host-Parasite Interaction and Host Susceptibility of Chagas� Disease
9. Pathogenesis and Modulation of Immune Function - Chagas� Disease
10. Autoimmunity and Pathogenesis of Chagas� Disease
11. Molecular Mimicry in Chagas� Disease
12. Parasite-Directed Pathogenesis of Chagas� Disease
13. Myocarditis - Immune-Mediated Myocardial Diseases
14. Dilated Cardiomyopathy - Immune Mediated Myocardial Diseases
Immunological Aspects of Chest Diseases
1. Immunological Aspects of Chest Diseases: The Case of Tuberculosis
2. Epidemiology - Tuberculosis
3. TB and AIDS
4. Clinical Tuberculosis
5. Experimental Studies of Tuberculosis
6. The Mouse Model of Chronic Tuberculosis
7. Host-Pathogen Interactions in TB
Immunological Aspects of Gastrointestinal and Liver Disease
1. Mucosal Immunity
2. Pernicious Anemia - Immune Mediated Diseases of the Gastrointestinal Tract
3. Gluten Sensitive Enteropathy - Immune Mediated Diseases of the Gastrointestinal Tract
4. Inflammatory Bowel Disease - Immune Mediated Diseases of the Gastrointestinal Tract
5. Liver Immunology
6. Hepatitis B - Diseases of the Liver
7. Hepatitis C - Diseases of the Liver
8. Other Hepatitis Viruses - Diseases of the Liver
9. Primary Biliary Cirrhosis - Diseases of the Liver
10. Primary Sclerosing Cholangitis - Diseases of the Liver
11. Autoimmune Hepatitis - Diseases of the Liver
Immunological Aspects of Endocrine Disease
1. Insulin-Dependent Diabetes Mellitus
2. Animal Models of Insulin-Dependent Diabetes Mellitus
3. ?-Cell Lesion: Nature of Effector Cells - Insulin Dependent Diabetes Mellitus
4. Rupture of Tolerance to ?-Cell Antigens - Insulin Dependent Diabetes Mellitus
5. Etiology of Insulin Dependent Diabetes Mellitus
6. Clinical Considerations of Insulin Dependent Diabetes Mellitus
Immune Mediated Neurological Syndromes
1. Multiple Sclerosis
2. Guillain-Barr� Syndrome
3. Myasthenia Gravis
4. Central Nervous System Systemic Lupus Erythematosus
5. Animal Models of Central Nervous System
Immunological Aspects of Renal Disease
1. Immunological Aspects of Renal Disease
2. Mechanisms of Immune Injury to the Kidneys
3. Specific Immune-Related Renal Diseases: IgA Nephropathy
4. Minimal Change Disease
5. Focal Sclerosing Glomerulosclerosis
6. Membranous Nephropathy
7. Membranoproliferative Glomerulonephritis
8. Rapidly Progressive Glomerulonephritis
9. Lupus Nephritis
10. Acute Poststreptococcal Glomerulonephritis
11. Mixed Cryoglobulinemia
Immunological Aspects of Transplantation
1. Immunological Aspects of Transplantation
2. Immunological Considerations of Transplantation
3. Laboratory Testing for Compatibility in Transplantation
4. Types of Solid Organ Allograft Rejection
5. Prevention and Management of Solid Organ Allograft Rejection
6. Solid Organ Transplantation Outcomes
7. Hematopoietic Stem Cell Transplantation
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