Biochemical Pharmacology - Medical Course Subject
Introduction
1. What is `biochemical pharmacology'?
2. What are drugs?
3. Drugs and drug target molecules
4. Drug molecules may or may not have physiological counterparts
5. Synthetic drugs may exceed the corresponding physiological agonists in selectivity
6. Metabolism of physiological mediators and of drugs
7. Strategies of drug development
Pharmacokinetics
1. Pharmacokinetics
2. Drug application and uptake - Pharmacokinetics
3. Drug distribution - Pharmacokinetics
4. Drug elimination: Kidneys
5. Drug elimination: Metabolism
Pharmacodynamics
1. Pharmacodynamics
2. Classes of drug receptors
3. Mechanisms and kinetics of drug receptor interaction
4. Drug dose-effect relationships in biochemical cascades
5. Spare receptors
6. Potency and efficacy
7. Partial agonism and the two-state model of receptor activation
8. Toxic and beneficial drug effects
The ionic basis of cell excitation
1. The ionic basis of cell excitation
2. Ion gradients across the cell plasma membrane
3. The physics of membrane potentials
4. Voltage-gated cation channels and the action potential
5. The origin of cell excitation
6. Anion channels
Drugs that act on sodium and potassium channels
1. Drugs that act on sodium and potassium channels
2. Local anesthetics
3. Sodium channel blockers as antiarrhythmic agents
4. Sodium channel blockers in epilepsia
5. Potassium channel blockers
6. Potassium channel openers
Some aspects of calcium pharmacology
1. Some aspects of calcium pharmacology
2. Calcium in muscle cell function
3. Calcium channel blockers
4. Digitalis (foxglove) glycosides
5. Calcium-dependent signaling by adrenergic receptors
Some aspects of neurophysiology relevant to pharmacology
1. Some aspects of neurophysiology relevant to pharmacology
2. Structure and function of synapses
3. Mechanisms of drug action on synapses
4. Pharmacologically important neurotransmitters and their receptors
5. Neurotransmitter receptors
6. Overview of the autonomic nervous system
G protein coupled receptors
1. G protein-coupled receptors
2. Structure and function of G protein-coupled receptors
3. The complexity of G protein signalling
4. Agonist-specific coupling
5. GPCR oligomerization
6. 'Allosteric' GPCR agonists and antagonists
Pharmacology of cholinergic synapses
1. Pharmacology of cholinergic synapses
2. Structure and function of the nicotinic acetylcholine receptor
3. Cholinergic agonists
4. Cholinergic antagonists
5. Cholinesterase antagonists
Pharmacology of catecholamines and of serotonin
1. Pharmacology of catecholamines and of serotonin
2. Biosynthesis and degradation of catecholamines
3. Pharmacokinetic aspects
4. Drug targets in catecholaminergic synapses
5. Adrenergic receptor agonists and antagonists
6. Inhibitors of presynaptic transmitter reuptake
7. Inhibition of vesicular storage
8. Indirect sympathomimetics
9. L-DOPA and carbidopa in the therapy of Parkinson's disease
10. False transmitters
11. Cytotoxic catecholamine analogs
12. Monoamine oxidase inhibitors
Pharmacology of nitric oxide NO
1. Pharmacology of nitric oxide (NO)
2. Vascular effects of nitric oxide
3. Nitric oxide synthase and its isoforms
4. Biochemical mechanisms of NO signaling
5. Role of NO in macrophages
6. NO releasing drugs
7. NOS inhibitors
Pharmacology of Eicosanoids
1. Pharmacology of Eicosanoids
2. Biosynthesis of eicosanoids
3. Cyclooxygenase inhibitors
4. Lipoxygenases and related drugs
Some principles of cancer pharmacotherapy
1. Some principles of cancer pharmacotherapy
2. Cell type-specific antitumor drugs
3. The cell cycle
4. Alkylating agents
5. Antibiotics
6. Antimetabolites
7. Inhibitors of mitosis
8. Monoclonal antibodies in tumour therapy
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